Hypotensive Agents for Controlled Hypotension in Endoscopic Sinus Surgery

Which hypotensive drugs are most effective and safe for reducing intraoperative bleeding in patients undergoing endoscopic sinus surgery (ESS)?This systematic review and network meta-analysis including 52 randomized clinical trials involving 3526 participants found that several agents were associated with reduced bleeding compared with placebo. Diltiazem, esmolol, dexmedetomidine, labetalol, and clonidine were effective; dexmedetomidine most strongly lowered mean arterial pressure; and esmolol and labetalol favored faster recovery times.Controlling hypotension for enhanced surgical field quality in ESS is possible with multiple safe and effective pharmacological options that can be tailored to the patient and surgical context.

Corresponding Author: Muhammed Elhadi, MBBCH, MSc, College of Medicine, Korea University, Anam-ro, Seongbuk-gu, Seoul 02841, South Korea (muhammed-elhadi@korea.ac.kr).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.