Proton Beam vs Intensity-Modulated Radiotherapy in Olfactory Neuroblastoma

Does adjuvant proton beam radiotherapy (PBRT) provide equivalent oncologic effectiveness while reducing radiation toxic effects compared with adjuvant intensity-modulated radiotherapy (IMRT) for patients with olfactory neuroblastoma (ONB)?In this propensity score–matched cohort study of 54 patients, patients treated with adjuvant IMRT and PBRT had similar rates of radiation toxic effects and no statistical difference in overall survival and recurrence-free survival.PBRT may not improve overall survival, recurrence-free survival, or radiation toxic effects relative to IMRT for patients with ONB.

Corresponding Author: Garret Choby, MD, Department of Otolaryngology–Head and Neck Surgery, University of Pittsburgh School of Medicine, 200 Lothrop St, Ste 500, Pittsburgh, PA 15213 (chobygw2@upmc.edu).

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