Original Investigation

Reevaluation of Enlarged Vestibular Aqueduct

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2025.2866

October 09, 2025 at 11:00 AM EDT

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What is the comprehensive landscape of the enlarged vestibular aqueduct (EVA)?In this cohort study and 21-year longitudinal analysis of 2774 Chinese patients with EVA, insights are provided on the natural history, phenotypic diversity, and molecular etiology of EVA.This cohort study provides an extensive phenotypic and genotypic characterization of EVA and potentially advances an understanding of its molecular underpinnings and clinical heterogeneity.

Corresponding Authors: Pu Dai, MD (daipu301@vip.sina.com), and Yongyi Yuan, MD, Senior Department of Otolaryngology Head and Neck Surgery (yyymzh@163.com), The 6th Medical Center of Chinese PLA General Hospital, 28# Fuxing Road, Beijing 100853, China.

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