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Contralateral Tonsil in p16-Positive Tonsil Squamous Cell Carcinoma

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2025.2410

October 16, 2025 at 11:00 AM EDT

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This Viewpoint examines current surgical guidelines and emerging evidence regarding the optimal treatment of patients with p16-positive oropharyngeal squamous cell carcinoma.

Corresponding Author: Karthik Rajasekaran, MD, University of Pennsylvania, 800 Walnut St, 18th Floor, Philadelphia, PA 19017 (karthik.rajasekaran@pennmedicine.upenn.edu).

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