Biochemical Profile of and Factors Associated With Recurrence in Primary Hyperparathyroidism
JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2025.1346July 24, 2025 at 11:00 AM EDT
What does the biochemical profile of patients with primary hyperparathyroidism reveal?In this cohort study of 1202 patients who underwent parathyroidectomy for primary hyperparathyroidism, single-gland disease and improved preoperative image localization were more likely among patients with a high level of parathyroid hormone (≥100 pg/mL) vs those with lower levels.Low baseline parathyroid hormone levels may be an independent risk factor for the presence of multigland disease and suboptimal localization on preoperative imaging.
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