JAMA Ophthalmology Clinical Challenge

Ophthalmoplegia and Ptosis After Cancer ImmunotherapyOphthalmoplegia and Ptosis After Cancer Immunotherapy—CaseOphthalmoplegia and Ptosis After Cancer Immunotherapy—Diagnosis

JAMA Ophthalmology 10.1001/jamaophthalmol.2026.0912

April 23, 2026 at 11:00 AM EDT

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An 82-year-old man presented with 4 months of fluctuating diagonal binocular diplopia and progressive bilateral ptosis. Examination in the strabismus clinic revealed variable ptosis and ophthalmoplegia in multiple gaze directions, with a large-angle esotropia and left hypotropia. What would you do next?

Corresponding Author: Federico G. Velez, MD, Stein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095-7002 (fvelez@mednet.ucla.edu).

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