JAMA Ophthalmology Clinical Challenge

Outer Retinal Disruption in a Young MaleOuter Retinal Disruption in a Young Male—CaseOuter Retinal Disruption in a Young Male—Diagnosis

JAMA Ophthalmology 10.1001/jamaophthalmol.2026.0807

April 16, 2026 at 11:00 AM EDT

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A 17-year-old male with a 3-month history of bilateral blurred vision and photophobia presents with placoid lesions in both eyes and further vision loss in the right eye. What would you do next?

Corresponding Author: Debra Anne Goldstein, MD, Department of Ophthalmology, Northwestern University, 259 E Erie St, 15th Floor, Chicago, IL 60611 (debra.goldstein@northwestern.edu).

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