Original Investigation

Influence of Intraocular Pressure on Clinical Decision-Making in Glaucoma Management

JAMA Ophthalmology 10.1001/jamaophthalmol.2025.5593

January 08, 2026 at 11:00 AM EST

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How do intraocular pressure (IOP) levels influence clinical decision-making in contemporary glaucoma management?In this cohort study, clinicians across 7 US academic ophthalmology institutions demonstrated higher glaucoma treatment rates at increasing IOP levels but were disproportionately more likely to initiate IOP-lowering treatment for IOPs of 22 mm Hg or higher than for IOPs less than 22 mm Hg.While clinicians generally use IOP as a continuous risk factor in their glaucoma treatment patterns, the historical definition of normal IOP being less than 22 mm Hg may still influence clinician decision-making in glaucoma management.

Corresponding Author: Brian C. Stagg, MD, MS, Moran Eye Center, University of Utah, 65 Mario Capecchi Dr, Salt Lake City, UT 84132 (brian.stagg@hsc.utah.edu).

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