Original Investigation

Manual Marking Guidance vs Digital Guidance System–Assisted Capsulorhexis in Phacoemulsification

JAMA Ophthalmology 10.1001/jamaophthalmol.2025.4448

November 13, 2025 at 11:00 AM EST

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Is manual marking–assisted capsulorhexis (MMAC) using a lens caliper (LC) noninferior to digital guidance–assisted capsulorhexis (DGAC) for the accuracy of capsulorhexis in phacoemulsification for age-related cataract?In this noninferiority randomized clinical trial of 156 participants, MMAC was found to be noninferior to DGAC in terms of the accuracy of capsulorhexis, postoperative best-corrected visual acuity, and intraocular lens stability.These findings support MMAC with an LC as a feasible auxiliary capsulorhexis technique, which does not require special equipment and is simple to operate and therefore might be appropriate if similar outcomes are obtained in other clinical practice settings.

Corresponding Author: Yizhi Liu, PhD, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, 7 Jinsui Rd, Guangzhou 510623, China (liuyizhi@gzzoc.com).

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