Brief Report

JC Virus–Related Retinopathy

JAMA Ophthalmology 10.1001/jamaophthalmol.2025.2235

July 17, 2025 at 11:00 AM EDT

Read the full article

Is the JC polyomavirus potentially associated with vision loss due to retinal infection rather than just the cortical visual changes typically reported in patients with progressive multifocal leukoencephalopathy?In this case report, we report a patient who exhibited isolated unilateral retinopathy related to JC polyomavirus infection of the retinal ganglion cell layer.Testing for JC polyomavirus should be considered in immunocompromised patients presenting with retinopathy of unexplained etiology.

Corresponding Author: Guillaume Martin-Blondel, MD, PhD, Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Docteur Baylac, TSA 40031, 31059 Toulouse CEDEX 9, France (martin-blondel.g@chu-toulouse.fr).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2025.2235?utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071725

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks