Brief Report

Outcomes and Treatments of Patients With Non–Small Cell Lung Cancer Who Received Pembrolizumab

JAMA Oncology 10.1001/jamaoncol.2026.0669

April 09, 2026 at 11:00 AM EDT

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What are the outcomes for patients with non–small cell lung cancer (NSCLC) after pembrolizumab discontinuation at 2 years?In this cohort study of 1480 patients with NSCLC, the survival rate 48 months after discontinuation was 76.9%, and 387 patients (26.1%) received a subsequent therapy, which was mostly chemotherapy and radiotherapy.The study results indicate that most patients were alive several years after immunotherapy cessation and immunotherapy rechallenge was uncommon.

Corresponding Author: Benjamin Besse, MD, PhD, Gustave Roussy, France, 114 Rue Edouard Vaillant, 94800 Villejuif, France (benjamin.besse@gustaveroussy.fr).

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