JAMA Oncology Clinical Challenge

Multiple Spinal Intradural Tumors and a Pigmented Skin LesionMultiple Spinal Intradural Tumors and a Pigmented Skin Lesion—CaseMultiple Spinal Intradural Tumors and a Pigmented Skin Lesion—Diagnosis

JAMA Oncology 10.1001/jamaoncol.2026.0386

April 30, 2026 at 11:00 AM EDT

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A 60-year-old woman presented with progressive right lower extremity radiculopathy and numbness, a pigmented skin lesion on the right side of the chest, and right ankle jerk reflex. Magnetic resonance imaging of the lumbar spine revealed multiple intradural, contrast-enhancing lesions. What is your diagnosis?

Corresponding Author: Satoshi Yamaguchi, MD, Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52241 (satoshi-yamaguchi@uiowa.edu)

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