Salvage Focal Therapy vs Radical Prostatectomy for Localized Radiorecurrent Prostate Cancer

How do cancer control and perioperative complications compare after salvage focal therapy vs salvage radical prostatectomy for localized radiorecurrent prostate cancer?In this cohort study with a mean matched cohort size of 554 patients with biopsy-confirmed, localized recurrent prostate cancer, 10-year cancer-specific survival and overall survival were not meaningfully different between salvage focal therapy and salvage radical prostatectomy. The adjusted odds of any and major complications were approximately 24 and 9 times higher, respectively, following salvage radical prostatectomy.Salvage focal therapy and salvage radical prostatectomy are both effective for treating localized radiorecurrent prostate cancer, though salvage focal therapy confers fewer perioperative complications.

Corresponding Author: Alexander Light, MBBS, Imperial Prostate, Division of Surgery, Department of Surgery and Cancer, Imperial College London, Du Cane Road, B Block, 1st Floor, London, W12 0NN, United Kingdom (a.light@imperial.ac.uk).

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