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Thyroid Nodule Molecular Classifiers—Reclaiming Deliberation in an Era of Automation

JAMA Oncology 10.1001/jamaoncol.2025.5606

January 02, 2026 at 11:00 AM EST

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This Viewpoint discusses the practice of molecular testing for the classification of thyroid nodules and explores related questions regarding automation, transparency, and clinical reasoning.

Corresponding Author: Juan P. Brito, MD, Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55902 (brito.juan@mayo.edu).

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