Metastatic Recurrence Among Adolescents and Young Adults With Cancer

What is the incidence of metastatic recurrence among adolescents and young adults with cancer, and how does survival differ between adolescents and young adults with metastatic recurrence compared to those with metastatic disease at diagnosis?In this cohort study of 48 406 adolescents and young adults diagnosed with cancer from 2006 to 2018, the 5-year cumulative incidence of metastatic recurrence varied by cancer type and increased with stage. Survival after metastatic recurrence was worse than after metastatic disease at diagnosis for most cancer types.The findings from this study highlight the overall burden and prognostic implications of metastatic disease in adolescents and young adults.

Corresponding Author: Ann Brunson, MS, Center for Oncology Hematology Outcomes Research and Training (COHORT), Division of Hematology and Oncology, University of California Davis Comprehensive Cancer Center, 4501 X St, Ste 3016, Sacramento, CA 95817 (ambrunson@health.ucdavis.edu).

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