Original Investigation

A Clinical Tool to Identify Incidental Meningioma for Early Outpatient Management

JAMA Oncology 10.1001/jamaoncol.2025.4821

November 20, 2025 at 11:00 AM EST

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Is the Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and Magnetic Resonance Imaging Tests (IMPACT) tool valid for predicting the risk of incidental meningioma progression, stratifying patients into early intervention, serial monitoring, or safe discharge from outpatient care?In this international multicenter cohort study including 1248 patients, the IMPACT tool accurately predicted the risk of incidental meningioma progression; 1 in 2 patients with high-risk disease progressed, compared with 1 in 4 with medium-risk and 1 in 25 low-risk disease. Accordingly, these groups can be stratified into early intervention, serial monitoring, or safe discharge.The IMPACT tool is an externally validated tool that may be used for the management of patients with incidental meningioma.

Corresponding Author: Abdurrahman I. Islim, MPhil, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom (abdurrahman.islim@manchester.ac.uk).

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