Research Letter

Reduced-Dose Enfortumab Vedotin, Treatment Continuity, and Survival in Urothelial Cancer

JAMA Oncology 10.1001/jamaoncol.2025.4566

November 13, 2025 at 11:00 AM EST

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This retrospective cohort study examines the association of upfront treatment with enfortumab vedotin plus pembrolizumab with clinical outcomes for patients with advanced urothelial cancer.

Corresponding Author: Ryan D. Chow, MD, PhD, Hospital of the University of Pennsylvania, 3400 Civic Center Blvd, Perelman Center, 10th Floor, South Pavilion Extension, Philadelphia, PA 19104 (chowr@pennmedicine.upenn.edu).

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