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Muscle Mass, Fragility, Weight Loss, and Cancer Treatment

JAMA Oncology 10.1001/jamaoncol.2025.4521

November 06, 2025 at 11:00 AM EST

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This Viewpoint discusses adverse effects associated with pharmacologic treatment of patients with cancer and overweight or obesity and emphasizes the importance of lifestyle modifications.

Corresponding Author: Colin E. Champ, MD, CSCS, Allegheny Health Network, Department of Radiation Oncology and Cancer Institute Exercise Oncology and Resilience Center, 200 S Jackson Ave, Pittsburgh, PA 15215 (colin.champ@ahn.org).

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