Artificial Intelligence–Detected Tumor-Infiltrating Lymphocytes and Outcomes in Anti–PD-1–Based Treated Melanoma

What is the association between artificial intelligence (AI)–detected tumor-infiltrating lymphocytes (TILs) with clinical outcomes in patients with advanced melanoma receiving first-line immune checkpoint inhibition?In this cohort study including 1202 patients, TILs in pretreatment metastases were quantified using a melanoma-specific publicly available AI model trained on an independent dataset. A 10% increase in TILs was associated with response, progression-free survival, and overall survival independent of clinical predictors.AI-detected TILs in pretreatment melanoma metastases were independently associated with response and survival.

Corresponding Author: Mark Schuiveling, MD, Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands (m.schuiveling@umcutrecht.nl).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.