Emerging EGFR-Targeted Therapy in Head and Neck Cancer

The emerging data of combinatorial approaches and novel EGFR-targeting therapeutic agents offer renewed optimism for patients with advanced HNSCC who have limited treatment options. Future progress will depend on novel agents leveraging a deeper understanding of tumor biology, innovative approaches to reduce on-target off-tumor toxic effects of targeting EGFR, and improving efficacy in the growing population of patients with HPV-positive HNSCC.

Corresponding Author: Jong Chul Park, MD, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (jpark73@mgh.harvard.edu).

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