Hypertension With High-Risk Features in Cryptogenic Stroke

Among patients with cryptogenic stroke, are high-risk features of hypertension associated with effect modification of anticoagulation compared to antiplatelet treatment for secondary prevention?In this exploratory analysis of a randomized clinical trial including 945 participants, high-risk features of hypertension were associated with effect modification of antithrombotic treatment assignment on recurrent ischemic stroke or systemic embolism. Anticoagulation was associated with fewer events among patients without high-risk features of hypertension, and no difference was observed between antithrombotic assignments among patients with high-risk features.The findings suggest that hypertension risk stratification may identify a subgroup with cryptogenic stroke who are likely to benefit from anticoagulation treatment.

Corresponding Author: Mohamed Ridha, MD, Department of Neurology, The Ohio State University, 333 W 10th Ave, Graves Hall, Ste 3172, Columbus, OH 43210 (mohamed.ridha@osumc.edu).

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