Plasma Phosphorylated Tau 217 and Amyloid Burden in Older Adults Without Cognitive Impairment

Can p-tau217 accurately identify older adults without cognitive impairment who have high levels of cortical amyloid burden?The meta-analysis indicated a large effect size for mean differences in p-tau217 when comparing individuals without cognitive impairment who had either high or low amyloid burden and demonstrated high discriminative accuracy between these groups.Plasma measures of p-tau217 can accurately identify individuals in the preclinical stage of Alzheimer disease where interventions are likely to have the most benefit in delaying or stopping disease progression.

Corresponding Author: Michael Malek-Ahmadi, PhD, Banner Alzheimer’s Institute, 901 E Willetta St, Phoenix, AZ 85006 (michael.malekahmadi@bannerhealth.com).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.