Obstructive Sleep Apnea, Positive Airway Pressure, and Implications of Early Treatment in Parkinson Disease

Is obstructive sleep apnea (OSA) associated with an increased risk of incident Parkinson disease (PD) diagnosis among US veterans?In this electronic health record–based cohort study of more than 11 million veterans with mean (SD) of 4.9 (1.8) years of follow-up, OSA was associated with incident PD, even after adjusting for competing risk of death, age, body mass index, and comorbidity burden. This risk was attenuated by OSA treatment with positive airway pressure.OSA may be a modifiable midlife risk factor for PD.

Corresponding Author: Lee E. Neilson, MD, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd, P3-PADRECC, Portland, OR 97239 (lee.neilson@va.gov).

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