Seizure Frequency Trends Over Time in Treatment-Resistant Focal Epilepsy

In focal treatment-resistant epilepsy, are seizure improvements over time in open-label trials due to disease-modifying effects or active management?In this multicenter, observational cross-sectional study of patients with focal treatment-resistant epilepsy who were followed for up to 3 years, 86 of 126 analyzed participants (68.3%) had significant seizure frequency reduction. There was no significant difference in seizure reduction based on device or medication changes.Improvement in seizure burden over time independent of intervention type suggests cautious interpretation of open-label studies that posit disease-modifying effects to explain seizure improvement in similar time courses.

Corresponding Author: Ojas Potnis, MD, Department of Neurology, NYU Langone Health, 550 1st Ave, New York, NY 10016 (ojas.potnis@nyulangone.org).

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