Brain Abnormalities in Children Exposed Prenatally to the Pesticide Chlorpyrifos

Is prenatal exposure to the pesticide chlorpyrifos (CPF) associated with disturbances in brain development?In this cohort study, progressively higher prenatal exposure to CPF was associated significantly with progressively greater alterations in brain structure, function, and metabolism and progressively poorer measures of motor speed and motor programming in a community sample of 270 youths aged 6 to 14 years.Prenatal CPF exposure was associated with long-term alterations in brain development and behavior.

Corresponding Author: Bradley S. Peterson, MD, Institute for the Developing Mind, Children’s Hospital Los Angeles, 4650 Sunset Blvd, Mail Stop 135, Los Angeles, CA 90027 (bpeterson@chla.usc.edu).

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