Research Letter

GLP-1 Receptor Agonists or SGLT2 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy

JAMA Network Open 10.1001/jamanetworkopen.2026.9917

April 30, 2026 at 11:00 AM EDT

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This cohort study evaluates the 3-year risk of nonarteritic anterior ischemic optic neuropathy among veterans with type 2 diabetes who initiated glucagon-like peptide-1 receptor agonists (GLP-1RAs) or a sodium-glucose cotransporter-2 (SGLT2) inhibitor.

Corresponding Author: Yan Xie, PhD, VA St Louis Health Care System, 915 N Grand Blvd, 151-JC, St Louis, MO 63106 (yan.xie3@va.gov).

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