Maternal Circulating sFlt-1:PlGF Ratio and Stillbirth

Is an elevated ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to reduced placental growth factor (PlGF) using clinically relevant cutoffs associated with an increased risk of stillbirth?In this case-control study of 39 stillbirths and 86 live births, a high sFlt-1:PlGF ratio was significantly associated with a 13-fold greater odds of stillbirth at the clinical cutoffs.These findings suggest that placental angiogenic imbalance may contribute to the pathogenesis of stillbirth in low-resource settings.

Corresponding Author: Mi-Sun S. Lee, PhD, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, FXB Bldg, Room 103, Boston, MA 02115 (mslee@hsph.harvard.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.