Original Investigation

Research Domain Criteria and Deaths by Suicide in the National Violent Death Reporting System

JAMA Network Open 10.1001/jamanetworkopen.2026.4024

March 30, 2026 at 11:00 AM EDT

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Can large language models be used to assign research domain criteria (RDoC) scores to suicide death narratives so as to better understand sex- and age-associated psychiatric morbidity among decedents?Using cross-sectional information from 72 585 deaths by suicide in the 2020 to 2021 National Violent Death Reporting System (NVDRS), methods of large language models were applied to score text narratives for RDoC domains. Decedents exhibited clinically elevated scores across most domains, with female and younger decedents scoring higher than male and older decedents, respectively.These findings suggest that, despite the relatively low prevalence of clinically depressed mood in NVDRS deaths by suicide, RDoC scores indicate substantial levels of clinically relevant symptoms at the time of death.

Corresponding Author: Susan D. Cochran, PhD, MS, Department of Epidemiology, UCLA Fielding School of Public Health, 650 Charles E. Young Dr S, Los Angeles, CA 90095 (cochran@ucla.edu).

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