Original Investigation

Laser Therapy for Sexual Health in Breast Cancer Survivors Receiving Aromatase Inhibitors

JAMA Network Open 10.1001/jamanetworkopen.2026.38937

October 15, 2026 at 11:00 AM EDT

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In this randomized clinical trial of breast cancer survivors receiving aromatase inhibitors, vulvovaginal CLT provided no additional benefit for sexual or vaginal health at 12 months. Improvements in both groups likely reflected FLT adherence, trial participation, or contextual factors rather than laser efficacy. High-quality sham-controlled trials remain essential before routine implementation.

Corresponding Author: Inmaculada Alonso, MD, MSc, PhD, Breast Cancer Unit–Gynecology, Obstetrics and Neonatology Service, University Hospital Joan XXIII Institut d’Investigació Sanitària Pere Virgili, C/Dr Mallafré 4. 43007 Tarragona, Spain (ialonso.hj23.ics@gencat.cat).

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