Amyloid Imaging and Genotype Disclosure and Short-Term Psychological Distress

Do psychological outcomes differ among cognitively unimpaired research participants aged 55 to 80 years who were disclosed 3 categorical outcomes of Alzheimer disease (AD) amyloid biomarker results as well as apolipoprotein genotypes?In this cohort study of 3414 individuals, both types of disclosure were associated with intrusive thoughts in a biomarker and gene dose association—greater risk categories were associated with higher scores on the Impact of Events Scale. In contrast, only biomarker results were associated with a change in the level of concern about developing AD dementia.These findings suggest that biomarker and genetic information had independent associations with psychological outcomes in cognitively unimpaired adults.

Corresponding Author: Joshua D. Grill, PhD, University of California, Irvine, 3204 Biological Sciences III, Irvine, CA 92697-4545 (jgrill@uci.edu).

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