Feeding Bottles With Different Venting Methods and Gastrointestinal Discomfort in Infants

Do bottom-vented bottles reduce the risk of mild gastrointestinal discomfort (MGD) in infants compared with teat-vented bottles?In this randomized clinical trial of 1055 infants aged 0 to 90 days, MGD prevalence at week 2 was not significantly different between the bottom-vented group (35.5%) and the teat-vented group (37.9%). However, an exploratory post hoc subgroup analysis suggested a potential benefit in infants aged 61 to 90 days, with a significantly lower prevalence in the bottom-vented group (21.1% vs 47.1%).These findings suggest potential benefits of bottom-vented bottles for decreasing the risk of MGD in infants older than 60 days.

Corresponding Authors: Hong-Tian Li, PhD (lihongtian@pku.edu.cn), and Yu-Bo Zhou, PhD (zhouyubo@bjmu.edu.cn), Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University Health Science Center, No. 38 Xueyuan Rd, Haidian District, Beijing 100191, China.

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