Research Letter

Longitudinal Quality of Life After Total Neoadjuvant Therapy for Rectal Cancer in the SHORT-FOX Trial

JAMA Network Open 10.1001/jamanetworkopen.2026.36038

September 25, 2026 at 11:00 AM EDT

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This cohort study examines quality-of-life and functional outcomes among participants in a clinical trial of total neoadjuvant therapy for advanced rectal cancer.

Corresponding Author: Arden M. Morris, MD, MPH, S-SPIRE Center, Department of Surgery, Stanford University School of Medicine, MC5552, 3145 Porter Dr, Wing C0, Palo Alto, CA 94304 (ammsurg@stanford.edu).

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