Original Investigation

Integrating Nonpharmacological Options Into Perioperative Pain Care

JAMA Network Open 10.1001/jamanetworkopen.2026.35900

September 25, 2026 at 11:00 AM EDT

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In this cluster randomized clinical trial of patients undergoing surgery, an EHR-embedded perioperative pain management intervention promoting nonpharmacologic pain care reduced opioid exposure without changes in patient-reported outcomes, suggesting potential for scalable EHR-based strategies to support safer postoperative pain management.

Corresponding Author: Andrea L. Cheville, MD, MSCE, Department of Physical Medicine and Rehabilitation, Mayo Clinic Rochester, 200 First St, Rochester, MN 55905 (cheville.andrea@mayo.edu).

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