Original Investigation

A Digital Therapeutic Intervention for Negative Symptoms of Schizophrenia

JAMA Network Open 10.1001/jamanetworkopen.2026.35753

September 25, 2026 at 11:00 AM EDT

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In this randomized clinical trial, CT-155 improved motivation and pleasure negative symptoms with a small-to-moderate effect size comparable with psychosocial interventions and pharmacologic treatment in psychiatry and was well tolerated and safe, thus representing a novel adjunctive therapy for schizophrenia. CT-155 may represent a scalable, accessible option for improving schizophrenia negative symptoms.

Corresponding Author: Abhishek Pratap, PhD, Global Clinical Development Mental Health and Eye Health, Boehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Rd, Ridgefield, CT 06877 (abhishek.pratap@boehringer-ingelheim.com).

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