Original Investigation

Mode of Birth and Stroke Risk After Childbirth Among Women With Moyamoya Disease

JAMA Network Open 10.1001/jamanetworkopen.2026.3112

March 23, 2026 at 11:00 AM EDT

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Is the mode of birth (cesarean vs vaginal) associated with differences in the risk of postpartum stroke among women with moyamoya disease?In this cohort study of 1683 women with moyamoya disease, the overall risk of postpartum stroke did not significantly differ by mode of birth. However, the effect of the mode of birth was significantly modified by the patient’s clinical onset type (eg, hemorrhagic, ischemic, or asymptomatic or nonvascular).These findings suggest that a routine preference for cesarean birth among women with moyamoya disease may be unnecessary.

Corresponding Authors: Jin-Man Jung, MD, PhD, Department of Neurology (dr.jinmanjung@gmail.com), and Ho Yeon Kim, MD, PhD, Department of Obstetrics and Gynecology (shinbi73@korea.ac.kr), Korea University Ansan Hospital, 123 Jeokgeum-ro, Ansan, Gyeonggi-do 15355, Republic of Korea.

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