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Fertility Treatments and the Risk of Kawasaki Disease Among Offspring

JAMA Network Open 10.1001/jamanetworkopen.2026.28586

August 12, 2026 at 11:00 AM EDT

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In this nationwide birth cohort study, all fertility treatments except intracytoplasmic sperm injection were associated with an increased risk of Kawasaki disease among offspring. These findings warrant further studies to clarify the underlying mechanisms.

Corresponding Author: Sachiko Baba, MD, PhD, Osaka Maternal and Child Information Center, Osaka Women’s and Children’s Hospital, Murodo-cho 840, Izumi 594-1101 Japan (sbaba@wch.opho.jp).

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