Original Investigation

Large Language Models Using Clinical Text in Pediatrics

JAMA Network Open 10.1001/jamanetworkopen.2026.2443

March 25, 2026 at 11:00 AM EDT

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How are large language models (LLMs) being used to analyze clinical text in pediatrics?This scoping review of 40 studies, all published within the past 2 years, found diverse clinical applications of LLMs, most commonly for clinical decision support, across multiple pediatric subspecialties. However, there was limited use of transparent reporting, standardized evaluation methods, and ethical or data privacy safeguards.This study’s results suggest that it is imperative to prioritize pediatric-specific data and adherence to rigorous reporting and evaluation standards to ensure safe and effective implementation of LLMs for analyzing clinical text in pediatrics.

Corresponding Author: Yair Bannett, Division of Developmental-Behavioral Pediatrics, Stanford University School of Medicine, 3145 Porter Dr, Palo Alto, CA 94304 (ybannett@stanford.edu).

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