Original Investigation

Area-Based Marginalization and Incidence of Childhood Cancer

JAMA Network Open 10.1001/jamanetworkopen.2026.23089

July 15, 2026 at 11:00 AM EDT

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Are area-based measures of social deprivation associated with childhood cancer incidence?In this population-based cross-sectional study of approximately 2.3 million children and 9063 pediatric cancer cases diagnosed in Ontario between 1999 and 2023, patients who lived in affluent neighborhoods had a 15% higher incidence rate of cancer than those in the least affluent areas.Set within Ontario’s universal health care system, this study’s results suggest that factors associated with affluence may contribute to an increased risk of childhood cancer, thus highlighting the need to consider broader sociodemographic factors when examining pediatric cancer epidemiology.

Corresponding Author: Maria Chiu, PhD, MSc(Epi), Pediatric Oncology Group of Ontario, 1014-480 University Ave, Toronto, ON M5G 1V2, Canada (mchiu@pogo.ca).

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