Sex Differences in Long-Term Overall and Cause-Specific Mortality in Patients With Cirrhosis

Are there any differences in the long-term overall and cause-specific mortality between male and female patients with cirrhosis?In this cohort study of 316 957 adults with cirrhosis, males had higher all-cause, cardiovascular, and hepatocellular carcinoma (HCC)–related mortality, whereas females had higher non-HCC liver-related mortality. Among patients younger than 50 years or with alcohol-associated cirrhosis, females had higher liver-related mortality but were less likely to undergo liver transplantation.These findings suggest that significant sex disparities exist in all-cause and cause-specific mortality in cirrhosis, supporting a sex-based strategy for monitoring and management of patients with cirrhosis.

Corresponding Author: Mindie H. Nguyen, MD, MAS, Division of Gastroenterology and Hepatology, Stanford University Medical Center, 780 Welch Rd, CJ250K, Palo Alto, CA 94304 (mindiehn@stanford.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.