Multifocal Noninvasive Deep Brain Stimulation to Enhance Cognition in Mild Cognitive Impairment

Does synergistic, dual-target, noninvasive neuromodulation of the striatum and cerebellum improve working memory (WM) in individuals with mild cognitive impairment (MCI), particularly those with early striatal degeneration?In this randomized, quadruple-blind, placebo-controlled crossover trial of 41 patients with MCI, dual-target stimulation significantly improved WM accuracy in individuals with early striatal degeneration. Stimulation-related gains were associated with striatal functional connectivity and cerebellar volume.These findings suggest that targeted engagement of cerebello-striatal circuits through coordinated dual-target noninvasive neuromodulation may represent a promising strategy to enhance WM in early stages of a neurodegenerative disease.

Corresponding Author: Irena Rektorová, MD, PhD, Neuroscience Programme, Central European Institute of Technology, Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic (irena.rektorova@fnusa.cz).

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