Population-Level Trends in Asthma Exacerbations After Introduction of Respiratory Biologics

Among adults with physician-diagnosed asthma in an integrated health system, what is the association of the introduction of biologics with population-level asthma exacerbation events?This cohort study of 5269 adults found that asthma exacerbation events declined significantly immediately after 2015, with sustained yearly decreases. Patients with more severe disease and elevated eosinophil counts experienced the largest reductions.These findings suggest that introduction of respiratory biologics for the treatment of moderate to severe asthma led to significant improvements in asthma outcomes, with reduction of the outcome gap between these patients and patients with mild asthma, who would usually not be eligible for these therapies.

Corresponding Author: Ayobami Akenroye, MBChB, MPH, PhD, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, 60 Fenwood Rd, Boston, MA 02115 (aakenroye@bwh.harvard.edu).

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