Prenatal Exposure to Acid-Suppressive Medications and Incident Risk of Inflammatory Bowel Disease in Children

Is prenatal acid-suppressive medication exposure associated with an increased risk of inflammatory bowel disease in children?In this cohort study of 2 631 880 mother-child pairs, prenatal acid-suppressive medication exposure was associated with modestly increased risks of inflammatory bowel disease, particularly for Crohn disease, although sibling comparison analyses showed no association.The very low absolute risk with null findings in sibling analyses suggests limited concern for most acid-suppressive medication use during pregnancy.

Corresponding Author: Hayeon Lee, PhD, Department of Biomedical Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, South Korea (wwhy28@khu.ac.kr); Tae Hyeong Kim, MD, PhD, Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, 892 Dongnam-ro, Gangdong-gu, Seoul 05278, South Korea (doctscales90@gmail.com).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.