Original Investigation

Diagnosing Urinary Tract Infection in Young Febrile Children in the Emergency Department

JAMA Network Open 10.1001/jamanetworkopen.2026.1741

March 13, 2026 at 11:00 AM EDT

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What is the diagnostic accuracy of UTICalc version 3.0 in predicting urinary tract infections (UTIs) for febrile children aged 2 to 24 months in the emergency department?In this diagnostic study with 2561 children, UTICalc showed strong discrimination, with an area under the receiver operating characteristic curve (AUROC) of 84.1% for the clinical model and an AUROC of 95.3% for the clinical and dipstick model.In this study, UTICalc had high accuracy in identifying UTIs in young febrile children, which may help guide testing and treatment decisions in the emergency department.

Corresponding Author: Ceilidh Kinlin, MD, Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Children’s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada (ckinlin@cheo.on.ca).

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