Variant Frequency and Colorectal Cancer–Specific Survival by Race and Ethnicity

Are there racial and ethnic differences in variant frequency, and is presence of variant associated with differences in colorectal cancer–specific survival by racial and ethnic group?In this cross-sectional study including 21 354 patients with colorectal cancer from a population-based database, Hispanic patients and non-Hispanic Black patients exhibited higher variant frequencies than non-Hispanic White patients. variant was associated with worse cause-specific survival among non-Hispanic Black patients compared with non-Hispanic White patients.These findings suggest that both tumor molecular characteristics, including variants, and socially mediated factors may contribute to racial and ethnic disparities in colorectal cancer outcomes.

Corresponding Author: Albert Y. Lin, MD, MPH, Division of Oncology, Department of Medicine, VA Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA 94304 (lina77@stanford.edu).

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