Machine Learning–Based Sleep Electroencephalographic Brain Age Index and Dementia Risk

Is a higher brain age index (BAI) derived from sleep electroencephalography (EEG) using machine learning associated with a higher risk of future dementia in community-dwelling older adults?In this individual participant data meta-analysis of 7105 adults from 5 longitudinal cohorts, every 10-year increase in BAI was associated with a 39% higher risk of incident dementia, independent of age, sex, apolipoprotein E ε4 status, and global cognition and comorbidities at the sleep study.These findings suggest that sleep EEG-based BAI may serve as a promising early digital marker for dementia risk stratification.

Corresponding Author: Yue Leng, PhD, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St, San Francisco, CA 94107 (yue.leng@ucsf.edu).

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