Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women

Do associations of plasma phosphorylated tau 217 (p-tau217) with incident mild cognitive impairment (MCI) and dementia vary by race, hormone therapy, age, or ε4 carrier status?In this cohort study among 2766 older women, associations of p-tau217 with incident dementia were larger in magnitude among women assigned to estrogen plus progestin vs placebo but did not vary for estrogen alone vs placebo. P-tau217 associations with MCI or dementia were larger in magnitude for women older than 70 years, ε4 carriers, and White compared with Black women.These findings underscore the value of p-tau217 and show that many factors should be considered when examining its associations with cognitive outcomes.

Corresponding Author: Aladdin H. Shadyab, PhD, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, #0725, La Jolla, CA 92093 (ahshadya@health.ucsd.edu).

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