New-Onset Atrial Fibrillation and Accelerated Kidney Function Decline in Working-Age Adults

Is new-onset atrial fibrillation associated with accelerated kidney function decline in working-age adults?In this cohort study of 23 510 adults with new-onset atrial fibrillation matched to 117 550 controls from a nationwide Japanese database, estimated glomerular filtration rate declined by 1.23 mL/min/1.73 m annually in the individuals with new-onset atrial fibrillation and by 0.94 mL/min/1.73 m in the control group (a statistically significant difference of 0.29 mL/min/1.73 m).These findings suggest that new-onset atrial fibrillation may accelerate kidney function decline in working-age adults, underscoring the importance of assessing cardiovascular, kidney, and metabolic health when atrial fibrillation is diagnosed in this population to prevent subsequent organ failure.

Corresponding Author: Shingo Fukuma, MD, PhD, Department of Epidemiology, Disease Control, and Prevention, Hiroshima University Graduate school of Biomedical and Health Sciences, 1-2-3, Kasumi, Minami, Hiroshima, 734-8553, Japan (shingo-fukuma@hiroshima-u.ac.jp).

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