Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals

Should reference intervals for plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) be adjusted by age, sex, body mass index (BMI), and/or kidney function?In this cross-sectional study of multiple population-based cohorts, comprising a total of 7958 cognitively unimpaired individuals aged 30 to 90 years, older age, lower BMI, and reduced kidney function were associated with increased plasma NfL and GFAP concentrations; female sex was associated with increased GFAP concentrations.These findings suggest that concentrations of NfL and GFAP should be interpreted in the context of an individual’s demographic and physiological profile.

Corresponding Author: Rebecca Z. Rousset, MSc, Neurochemistry Laboratory, Amsterdam UMC, location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands (r.z.rousset@amsterdamumc.nl).

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