Rural-Urban Disparities in Hepatocellular Carcinoma Incidence and Mortality

Are there disparities in hepatocellular carcinoma (HCC) incidence and mortality between rural and urban populations in the US?In this cohort study, population-based analysis from 2001 to 2022 demonstrated stable or increased HCC incidence and mortality rates in rural counties and decreased rates in urban counties. These trends were particularly evident among the non-Hispanic White population.These findings emphasize the growing disparity between rural and urban populations in HCC incidence and mortality trends and highlight the need for enhanced strategies in liver disease prevention, early detection, and health care accessibility in rural regions.

Corresponding Author: Tarik Demir, MD, Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Canon Dr, 1300L Lincoln Tower, Columbus, OH 43210 (Tarik.Demir@osumc.edu).

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