Prenatal Azithromycin Exposure and Risk of Neurodevelopmental Disorders in Children

What is the risk of neurodevelopmental disorders (NDDs) in children prenatally exposed to azithromycin compared with those exposed to β-lactams or unexposed to antibiotics during pregnancy?In this cohort study of 15 527 mother-infant dyads, late pregnancy azithromycin exposure was associated with a lower incidence of composite NDDs compared with all other antibiotics and β-lactams, but no statistically significant difference was found compared with no prenatal antibiotic exposure.These findings suggest that late pregnancy azithromycin exposure may be associated with a lower incidence of NDDs compared with other antibiotics, but more research is needed.

Corresponding Author: Xuerong Wen, PhD, Department of Pharmacy Practice xuerongwen@uri.edu).

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